WebApr 30, 2011 · Cisplatin, cis-diamminedichloro-platinum(II) or [(NH 3) 2 PtCl 2], is one of the most widely used antitumor drugs and is most active against a variety of tumors, especially testicular and ovarian cancers [1–3].However, its clinical success is limited by severe side effects which have led to the development of second-generation platinum compounds … WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …
DFT study of the molecular and crystal structure and vibrational ...
Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side … See more Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some See more Cisplatin is the square planar coordination complex cis-[Pt(NH3)2Cl2]. The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic … See more Syntheses of cisplatin start from potassium tetrachloroplatinate. Several procedures are available. One obstacle is the facile formation of Magnus's green salt (MGS), which has the … See more Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose … See more Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one … See more The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University See more Cisplatin has been studied with Auger therapy to increase the therapeutic effects of cisplatin, without increasing normal tissue toxicities. See more WebFig. 4 displays the ORTEP diagrams of their molecular structures whereas the main crystallographic data and selected bond distances and angles can be found in the ESI† section (Tables S2–S3†). All compounds crystallize in the monoclinic system, space group C 12/ c 1 ( 1 ), P 12 1 / c 1 ( 3 , 7 ) or P 12 1 / n ( 5 , 6 ) with exception of ... green bay wi va audiology clinic
Structure and bonding in cisplatin and other Pt(II) …
Webwww.ncbi.nlm.nih.gov WebMolecular structure, IR spectra, and chemical reactivity of cisplatin and transplatin DFT studies, basis set effect and solvent effect WebA DFT conformational and vibrational analysis of a single molecule of cisplatin (cis-[Pt(NH3)2Cl2]) was performed by means of PW91 functional and LANL08 ECP basis set for the Pt atom. 3-21G and 3 ... flowers in buxton maine