Cisplatin-induced nephrotoxicity

Author: vnjs

August undefined, 2024

WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH …

Ethanol extract of Crataeva nurvala stem bark reverses cisplatin ...

WebDive into the research topics of 'Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity'. Together they form a unique fingerprint. Capparaceae Medicine & Life Sciences 100%. Proximal Kidney Tubule Medicine & Life Sciences 50%. Cisplatin Medicine ... WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. portland oregon fishing guide

MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin ...

WebFeb 1, 2024 · Abstract Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity. WebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6]. WebNational Center for Biotechnology Information optimi health stock cse

Cisplatin-induced nephrotoxicity in an outpatient setting

Caspase 3/GSDME-dependent pyroptosis contributes to ... - Nature

WebCisplatin, a widely used chemotherapy drug, induces acute kidney injury, which limits its use and efficacy in cancer treatment. However, the molecular mechanism of cisplatin-induced nephrotoxicity is currently unclear. Using pharmacological and gene knockout models, we now demonstrate a pathological role for p53 in cisplatin nephrotoxicity. WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … optimi lynnwood campusWebBoldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3 optimi learning contact details

"WebOct 26, 2024 · The Cisplatin-induced nephrotoxicity was evident from the elevated levels of creatinine, urea, uric acid, and renal tissue MDA and also decreased levels of SOD, CAT, GPX, and GSH in renal tissue. Administration of Gallic acid significantly modulated nephrotoxicity markers, gene expression variations, and histopathological damage. … " - Cisplatin-induced nephrotoxicity

Cisplatin-induced nephrotoxicity

Cisplatin nephrotoxicity: new insights and therapeutic implications

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Did you know?

WebApr 15, 2024 · Eventually, nephrotoxicity complicated by hypomagnesaemia was confirmed, and cisplatin-induced nephrotoxicity led to the final diagnosis of a familial … WebJan 3, 2024 · All of these drugs can affect the glomerulus, tubules, interstitium, or renal microvasculature via different mechanisms, with clinical manifestations that range from an asymptomatic elevation of serum creatinine and electrolyte disorders to acute kidney injury requiring dialysis.

WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause acute kidney injury and chronic kidney disease. Preclinical studies have provided insights into the cellular … WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in …

WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known …

WebOct 3, 2016 · Nephrotoxicity is one of the major and most serious toxicities caused by cisplatin and is known to be its dose-limiting toxicity [ 1 ]. Cisplatin-induced nephrotoxicity (CIN) occurs in 30–40 % of patients receiving cisplatin and is recognized to be cumulative, dose related, and usually reversible [ 2, 3 ].

WebFeb 16, 2016 · Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15–29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxicity (defined as … portland oregon fire department non emergencyWebFeb 2, 2024 · Celastrol, a potent chemotherapeutic agent, could ameliorate cisplatin-induced nephrotoxicity through suppressing NF-κB and protecting mitochondrial function in vitro and in vivo (Yu et al., 2024). Similarly, polysulfide and H2S could afford protection against cisplatin-caused nephrotoxicity via persulfidating STAT3 and IκKβ and … optimi learning portal registerhttp://medicine-opera.com/wp-content/uploads/2008/05/cisplatin-nephrotoxicity.pdf optimi websiteWebThe major side effect of cisplatin is renal damage. Persea americana has been used in the Indian system of medicine to treat various diseases. This study aims to investigate the nephroprotective activity of hydroalchoholic extract of P. americana (HEPA) leaves on cisplatin induced nephrotoxicity in albino wistarrats. optimi health stock priceWebA multivariate analysis indicated that magnesium preloading significantly reduced cisplatin-induced nephrotoxicity throughout the entire period from after the first administration (odds ratio: 0.262, 95% confidence interval: 0.106-0.596 during the first cycle, and odds ratio: 0.234, 95% confidence interval: 0.129-0.414 during all cycles). optimi learning portal login appWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … portland oregon fire mapWebCisplatin toxicity arises most characteristically in the kidneys, cochlea, bone marrow, gastrointestinal mucosa and nerves (with altered taste, peripheral neuropathy and encephalopathy). The kidneys are particularly susceptible to cisplatin toxicity, as they are almost exclusively responsible for its excretion. portland oregon fbi