WebTo discover the enzyme responsible for this chemistry, we studied the biosynthesis of the cylindrocyclophanes. Chapter 2 describes the discovery and the validation of the cylindrocyclophane (cyl) biosynthetic gene cluster. The candidate cyl gene cluster was identified from the genomic sequence of the cylindrocyclophane producer. WebCylindrocyclophane F C36H56O4 - PubChem compound Summary Cylindrocyclophane F Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical …
Incorporation and modification of fatty acids in cyanobacterial …
WebCylindrocyclophane biosynthesis, however, is unique in possessing both a freestanding terminating enzyme and a C-terminal TE domain on the final module of its type I modular PKS assembly line (CylH). This is surprising, as termination via a type III PKS should not require a type I TE domain. Cylindrocyclophanes are a class of cyclophane, a group of aromatic hydrocarbons composed of two benzene rings attached in a unique structure. Cylindrocyclophanes were the first cyclophanes found in nature, isolated from a species of cyanobacteria, and have proven to be an interesting … See more Before the cylindrocyclophanes, the cyclophanes had all been produced synthetically. However, when a culture of the cyanobacteria Cylindrospermum lichenforme was being evaluated for antitumor activity, … See more Cylindrocyclophanes are all [7,7] paracyclophanes, differing only in the functional groups present on C-1, C-14, C-29, and C-33. There are currently 16 cylindrocyclophanes that have been identified: cylindrocyclophanes A - F, A4 - A1, C4 - C1, F4, … See more When cylindrocyclophane A was discovered, it was during an evaluation of the cyanobacteria Cylindrospermum lichenforme for antitumor activity. It was shown that … See more Since the cylindrocyclophanes have such a unique structure and exciting biological possibilities due to their cytotoxicity, there have been numerous efforts to create them synthetically in the laboratory. One of the first attempts was the total synthesis of cylindrocyclophane … See more popo tea shop
Assembly line termination in cylindrocyclophane biosynthesis: …
WebCylindrocyclophane A4 C36H52Cl4O6 CID 46939337 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebThe structures of the ketones 1004 and 1006 are analogous to the p-cyclophane 992 in Scheme 7.4, and all react to give the hydrocarbons 1005 and 1007 in good yields (5).The … WebJan 10, 2024 · The cylindrocyclophanes (e.g. cylindrocyclophane F 1), nocuolin A (2), 1-alkenes (e.g.3) and a wide range of lipopeptides (e.g. hapalosin A, 4) are examples of cyanobacterial natural products whose biosynthesis involves FAAL-mediated activation and incorporation of fatty acids.15,24,35–37 FAALs can be found in cyanobacterial genomes … popote spanish translation