WebJul 19, 2024 · Compounds 1–9 all exhibited considerable cytotoxicity toward U251MG cells (Figure S1 and Table S1), with smenospongine (3) and dictyoceratin A (7) showing the most potent effects. Furthermore, 1 – 2 and 4 – 7 were significantly cytotoxic toward Panc-1 cells as well ( Figure S2 ). WebDec 16, 2015 · Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure-activity relationship of the natural compounds 1 and 2 isolated from a marine sponge.
Exploring Bioactive Marine Natural Products and ... - Springer
WebMar 28, 2024 · Two new antimicrobial sesquiterpenoids, dictyoceratin-A (3a) and -B (4a) were isolated from the Okinawan marine sponge sp. along with known compounds, furospinulosin-1 (1) and ilimaquinone (2). WebJan 1, 1986 · Two new antimicrobial sesquiterpenoids, dictyoceratin-A (3a) and -B (4a) were isolated from the Okinawan marine sponge Hippospongia sp. along with known … chin\u0027s sb
Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids …
WebApr 1, 2024 · Using various chromatographic methods, five new sesquiterpene derivatives named smenohaimiens A-E (1-5) and five known, 19-hydroxy-polyfibrospongol B (6), ilimaquinone (7), dictyoceratin C (8), polyfibrospongol A (9), and polyfibrospongol B (10) were isolated from the marine sponge Smenospongia cerebriformis Duchassaing & … WebOral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. WebMay 31, 2024 · Dictyoceratin-C; Agelasine D; Download chapter PDF 1 Introduction. Pathways for exploring bioactive natural products in the quest for novel drug discovery “seeds” may be broadly classified into two categories: target-specific screening and phenotypic screening. Target-specific screening identifies compounds effective for an … grant 7 clear coat auto paint