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WebOct 5, 2024 · While diphenhydramine is generally a safe medication for those under the age of 65, it does cause drowsiness because it crosses the blood brain barrier and affects the central nervous system. ... It is a histamine-1 antagonist medication that can be used to both stop itchiness due to histamine release as well as the anxiety that may come along ... WebApr 4, 2024 · In addition, drugs such as diphenhydramine can cause dependence when taken for longer than directed (usually two weeks), and they have other risks, such as constipation, confusion, dizziness, and ... WebStop using this product and tell your doctor if your condition worsens, if symptoms do not improve within 7 days or last after 7 days of treatment, or if symptoms clear up and return in a few days. small grain calfskin leather rockstud bag