Sin1 mediated
Webb21 mars 2024 · This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding … WebbSin1 over‐expression enhanced osmotic stress‐induced phosphorylation of ATF‐2 and ATF‐2‐mediated transcription, whereas knockdown of Sin1 expression by siRNA suppressed these responses. Moreover, a reduction in Sin1 expression suppressed osmotic stress‐induced apoptosis and the expression of Gadd45β, one of the ATF‐2 …
Sin1 mediated
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WebbHere we report that phosphorylation of Sin1 at Thr 86 and Thr 398 suppresses mTORC2 kinase activity by dissociating Sin1 from mTORC2. Importantly, Sin1 phosphorylation, triggered by S6K or Akt, in a cellular context-dependent manner, inhibits not only insulin- or IGF-1-mediated, but also PDGF- or EGF-induced Akt phosphorylation by mTORC2, … Webb27 okt. 2013 · Sin1 phosphorylation suppresses mTORC2 kinase activity towards phosphorylating Akt in vitro. (a,b) HEK293T cells were transfected with the indicated Flag-tagged Sin1 constructs. At 36 h...
Webb14 nov. 2024 · Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 November 2024 Journal of Molecular Cell Biology 11 (2) DOI: 10.1093/jmcb/mjy065 License CC BY 4.0... Webb11 aug. 2015 · SIN1 phosphorylation mediates a positive feedback loop between Akt and mTORC2 Summary The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself.
Webb31 jan. 2024 · As shown in our previous study, Sin1 is specifically required for bone marrow B cell development via the Akt-mediated phosphorylation of FoxO1 to inhibit IL-7 … WebbThe pathological Sin1-R81T mutation exhibited elevated oncogenic activity in part by bypassing Sin1 phosphorylation-mediated negative regulation of Akt-pS473. (a–c) …
Webb3 okt. 2024 · Mechanistically, we found that p38 is activated in response to cystine stimulation, and co-immunoprecipitation experiments suggested that p38 regulated the …
Webb2 dec. 2024 · Sin1 expression is elevated in various cancer types, including liver cancer ( 31–33 ). Highly expressed Sin1 promotes cell proliferation, cell invasion, and epithelial-to-mesenchymal transition (EMT) via mTORC2–AKT signaling ( 32, 34, 35 ). Nonetheless, the regulation of Sin1 towards these distinct pathological events need further elucidation. rayman legends cloud of darknessWebb19 nov. 2024 · S ty1/Spc1- in teracting protein 1 (Sin1), also known as mitogen-activated protein kinase ( MAPK) a ssociated p rotein (MAPKAP)1, was first identified in 1999 in fission yeast Schizosaccharomyces pombe as an adaptor protein interacting with Sty1 (also known as Spc1), a member of the eukaryotic stress-activated protein kinase … rayman legends coloring pagesWebb4 okt. 2024 · Sin1 (stress-activated protein kinase-interacting protein) as an essential component of mTORC2 (mammalian target of rapamycin complex 2) is required for cell … rayman legends costumesWebb11 aug. 2015 · Current knowledge of the structure and functions of Sin1 are summarized, focusing specifically on its protein interaction network and its roles in the mTOR pathway that could account for various cellular functions of mTOR in growth, metabolism, immunity and cancer. Expand 2 Highly Influenced PDF View 11 excerpts, cites background Save Alert rayman legends characters wikiWebb14 sep. 2024 · A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity. Sinem Yilmaz, Department of Biotechnology, Graduate School of Natural and Applied Sciences, Ege University, Izmir, Turkey. rayman legends couch co opWebb14 sep. 2024 · A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity. Sinem Yilmaz, Department of Biotechnology, Graduate School of Natural and Applied Sciences, Ege University, Izmir, Turkey. rayman legends crack onlyWebb29 okt. 2024 · Therefore, Sin1 serves as the key component to mediate the cross talk between physiological signals and proper mTORC2 function. Although mTOR and Rictor … simplex heritage copper tea kettle